Molecule, 6-Bio, clears up toxic waste inside cells in Parkinson's disease


20 Jun 2017

Molecule, 6-Bio, clears up toxic waste inside cells in Parkinson's disease

Molecule, 6-Bio, clears up toxic waste inside cells in Parkinson's disease

Dr Ravi Manjithaya, Intermediate Fellow

JNCASR, Bangalore

Autophagy is cell’s own mechanism to clean up unwanted junk. This is usually in the form of protein clumps in case of neurodegenerative disease like Parkinson’s, Alzheimer’s, Huntington’s and Amyotrophic Lateral Sclerosis. Not clearing these toxic cellular clumps eventually leads to death of the brain cells. As these cells are irreplaceable, the decline in numbers over time results in manifestation of the above diseases. To compound the problem, autophagy is dysfunctional in such cases. Our studies identified a drug-like small molecule that can boost autophagy and thus help cells clear the toxic protein clumps and save cells from certain death. While studying how this molecule, 6-Bio, enhances autophagy, we identified a possible braking mechanism that exists in normal cells to prevent perhaps rapid autophagy flux. 6-Bio relieves the cell of these brakes thus accelerating the autophagy process. All the way from yeast cells to a mouse model for Parkinson’s, 6-Bio’s autophagy boosting ability helped cells clear protein clumps and survive. This understanding of a basic mechanism could possibly be an exciting target for identifying and developing therapeutic solutions for neurodegenerative disorders via autophagy induction.

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity. S. N. Suresh, Aravinda K. Chavalmane, Vidyadhara D J, Haorei Yarreiphang, Shashank Rai, Abhik Paul, James P Clement, Phalguni Anand Alladi & Ravi Manjithaya

Media Reports: 

https://indiabioscience.org/news/2017/autophagy-on-the-road-to-curing-neurodegenerative-diseases http://timesofindia.indiatimes.com/city/bengaluru/molecule-discovery-offers-ithope-for-parkinsons-cure/articleshow/58798981.cms
http://www.natureasia.com/en/nindia/article/10.1038/nindia.2017.68
http://timesofindia.indiatimes.com/city/bengaluru/molecule-discovery-offers-ithope-for-parkinsons-cure/articleshow/58798981.cms
http://fountainink.in/?p=9015