Publications and Presentations

1.      Verma R, Balakrishnan L, Sharma K, Khan AA, Advani J, Gowda H, Tripathy SP, Suar M, Pandey A, Gandotra S, Prasad TS, Shankar S. A network map of Interleukin-10 signaling pathway. J Cell Commun Signal. 2016 Mar;10(1):61-7.

2.      Nagarajan SN, Upadhyay S, Chawla Y, Khan S, Naz S, Subramanian J, Gandotra S, Nandicoori VK. Protein kinase A (PknA) of Mycobacterium tuberculosis is independently activated and is critical for growth in vitro and survival of the pathogen in the host. J Biol Chem. 2015 Apr 10;290(15):9626-45.

3.      Kozusko K, Tsang VH, Bottomley W, Cho YH, Gandotra S, Mimmack M, Lim K, Isaac I, Patel S, Saudek V, O'Rahilly S, Srinivasan S, Greenfield JR, Barroso I, Campbell LV, Savage DB.Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy. Diabetes. 2015 Jan;64(1):299-310.

4.      Singh LK, Dhasmana N, Sajid A, Kumar P, Bhaduri A, Bharadwaj M, Gandotra S, Kalia VC, Das TK, Goel AK, Pomerantsev AP, Misra R, Gerth U, Leppla SH, Singh Y. clpC operon regulates cell architecture and sporulation in Bacillus anthracis. Environ Microbiol. 2015 Mar;17(3):855-65.

5.      Chauhan P, Reddy PV, Singh R, Jaisinghani N, Gandotra S, Tyagi AK. Secretory phosphatases deficient mutant of Mycobacterium tuberculosis imparts protection at the primary site of infection in guinea pigs. PLoS One. 2013 Oct 18;8(10):e77930.

  1. Gandotra S*, Lim K, Girousse A, Saudek V, O’Rahilly S, Savage DB* human frameshift mutations affecting the carboxyl terminus of perilipin increase lipolysis by failing to sequester the adipose triglyceride lipase (ATGL) coactivator, ab-hydrolase containing 5 (ABHD5). J Biol Chem 2011 Oct 7;286(40):34998-5006. (*co-corresponding authors)
  2. Gandotra S, Le Dour C, Bottomley W, Cervera P, Giral P, Reznik Y, Charpentier G, Auclair M, Delépine M, Barroso I, Semple RK, Lathrop M, Lascols O, Capeau J, O’Rahilly S, Magré J, Savage DB, Vigouroux C. Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy. New England Journal of Medicine. 2011 Feb 24;364(8):740-8.
  3. Gandotra S, Lebron M, Ehrt S. The Mycobacterium tuberculosis proteasome active site threonine is essential for persistence in vitro and in mice yet dispensable for replication and resistance to nitric oxide. PLOS Pathogens. 2010 Aug 12;6(8). pii: e1001040.
  4. Gandotra S, Schnappinger D, Monteleone M, Hillen W, Ehrt S. In vivo  gene silencing identifies the Mycobacterium tuberculosis proteasome as essential for the bacteria to persist in mice. Nature Medicine. 2007 Dec 13(12):1515-1520.
  5. Gandotra S, Jang S, Murray PJ, Salgame P, Ehrt S. Nucleotide-Binding Oligomerization Domain Protein 2-Defficient mice control infection with Mycobacterium tuberculosis. Infection & Immunity. 2007 Nov 75(11):5127-5134.
  6. Shi S, Blumenthal A, Hickey CM, Gandotra S, Levy D, Ehrt S. Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1. Journal of Immunology. 2005 Sep 1;175(5):3318-28.
  7. Hisert KB, MacCoss M, Shiloh MU, Darwin KH, Singh S, Jones RA, Ehrt S, Zhang Z, Gaffney BL, Gandotra S, Holden DW, Murray D, Nathan C. A glutamate-alanine-leucine (EAL) domain protein of Salmonella controls bacterial survival in mice, antioxidant defence and killing of macrophages: role of cyclic diGMP. Molecular Microbiology. 2005 Jun;56(5):1234-45.
  8. Varadarajan P, Mahalingam S, Liu P, Ng SB, Gandotra S, Dorairajoo DS, Balasundaram D. The functionally conserved nucleoporins Nup124p from fission yeast and the human Nup153 mediate nuclear import and activity of the Tf1 retrotransposon and HIV-1 Vpr. Molecular Biology of the Cell. 2005 Apr; 16(4):1823-38. Epub 2005 Jan 19.